X-Linked Lymphoproliferative Disease: Twenty-Five Years after the Discovery

X-Linked Lymphoproliferative Disease

2B4 is a surface molecule involved in activation of the natural killer (NK) cell-mediated cytotoxicity. It binds a protein termed Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which in turn has been proposed to function as a regulator of the 2B4-associated signal transduction pathway. In this study, we analyzed pat...

Lymphocytic vasculitis in X-linked lymphoproliferative disease.

Systemic vasculitis is an uncommon manifestation of X-linked lymphoproliferative disease (XLP), a disorder in which there is a selective immune deficiency to Epstein-Barr virus (EBV). The molecular basis for XLP has recently been ascribed to mutations within SLAM-associated protein (SAP), an SH2 domain-containing protein expressed primarily in T cells. The authors describe a patient who died as...

The First Twenty-Five Years

At the initial meeting of the AES, held in November 1927, among the resolutions passed, two were of particular significance. They were: 1. That the object of this Society be to promote the study and discussion of epidemiological problems. 2. That membership shall consist only of those active and interested in the study of epidemiology. Although the by-laws did not specify that unfinished work c...

Twenty-Five Years Ago

Cuba at the crossroads: twenty-five years after the revolution

W~~lor the I irst and only time during our stay in Cuba, we m i are subject to strict security no cameras, no bags. The factory is a prime target for CIA saboteurs. In the foreground a welcoming committee from the complex is clustering lightly. Perhaps 200 people: women favouring bright bandanas to cover rollers in their hair, some o f the men a fleeting cord or denim peaked caps, all save lot ...